Image Credit: Prime
Boasting a cast of celebrated Hollywood figures, such as Nicole Kidman and Jamie Lee Curtis, Scarpetta is generating buzz. The fresh Prime Video program, which premiered on March 11, 2026, centers on a medical examiner who deciphers puzzling offenses using scientific methods.
Nicole Kidman — Dr. Kay Scarpetta
Nicole stands as one of the movie world’s most prominent figures. After appearing in many films and television shows, the esteemed Academy Award winner embodies the protagonist, Dr. Kay Scarpetta, the adept medical examiner leveraging her technological expertise to resolve enigmas and wrongdoings.
The Australian actress’s career picked up steam in the ’90s by taking roles in the movies Far and Away, To Die For, Batman Forever, Practical Magic, and Eyes Wide Shut. In 2002, Nicole captured an Oscar for portraying Virginia Woolf in The Hours. She also gained nominations for her roles in Moulin Rouge!, Rabbit Hole, Lion, and Being the Ricardos, where she played Lucille Ball.
On television, Nicole has solidified her presence on the small screen through her performances in The Undoing, Nine Perfect Strangers, Big Little Lies, and The Perfect Couple.
Courtesy of Connie Chornuk/Prime
Jamie Lee Curtis — Dorothy Scarpetta
Most people recognize Jamie for her quintessential “last woman standing” status from the Halloween series, but she’s also established herself in film and TV by appearing in Blue Steel, My Girl, Freaky Friday and its sequel, Freakier Friday, Christmas with the Kranks, Knives Out, Everything Everywhere All at Once, and The Last Showgirl. Jamie clinched the Oscar for Best Supporting Actress for her work in Everything Everywhere All at Once.
In the realm of TV, she’s risen to fame for her role in The Bear. Within Scarpetta, Jamie embodies Kay’s older sibling, Dorthy.
Ariana DeBose — Lucy Farinelli-Watson
Ariana DeBose takes on the role of Dorothy’s daughter, Lucy, and the actress showcases a versatile range of talents. In theater, she is celebrated for Hamilton, A Bronx Tale, and Summer: The Donna Summer Musical. Subsequently, she utilized her stage expertise to host the Tony Awards on various occasions.
Ariana likewise translated her musical talent to the screen by featuring in the contemporary interpretation of West Side Story!
Bobby Cannavale — Former Detective Pete Marino
Bobby Cannavale embodies a former law enforcement officer in the series, and the actor has ascended to prominence in recent years. Distinguished for his TV roles, Bobby has graced the screen in Will & Grace, earning him an Emmy for Guest Actor, Vinyl, Mr. Robot, Blue Bloods, Homecoming, Nine Perfect Strangers, and The Watcher.
Simon Baker — FBI Profiler Benton Wesley
Lastly, Simon Baker plays the FBI profiler within the show. The native Australian has been featured in a diverse array of film and television roles over the previous two decades, notably The Guardian, which garnered him a Golden Globe nomination for Best Actor in a Television Series – Drama, and The Mentalist, securing him an Emmy nomination.
Simon has also been seen in several films, including L.A. Confidential, The Devil Wears Prada, and Margin Call.